Lactate as a determinant of neuronal excitability, neuroenergetics and beyond - Development and Plasticity of Neural Networks Access content directly
Journal Articles Neurobiology of Disease Year : 2023

Lactate as a determinant of neuronal excitability, neuroenergetics and beyond

Abstract

Over the last decades, lactate has emerged as important energy substrate for the brain fueling of neurons. A growing body of evidence now indicates that it is also a signaling molecule modulating neuronal excitability and activity as well as brain functions. In this review, we will briefly summarize how different cell types produce and release lactate. We will further describe different signaling mechanisms allowing lactate to fine-tune neuronal excitability and activity, and will finally discuss how these mechanisms could cooperate to modulate neuroenergetics and higher order brain functions both in physiological and pathological conditions.
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hal-04132442 , version 1 (10-10-2023)

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Bruno Cauli, Isabelle Dusart, Dongdong Li. Lactate as a determinant of neuronal excitability, neuroenergetics and beyond. Neurobiology of Disease, 2023, Astrocyte metabolism in Neurodegeneration, 184, pp.106207. ⟨10.1016/j.nbd.2023.106207⟩. ⟨hal-04132442⟩
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