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Glial cells CTG repeat contractions Glutamate Dilated cardiomyopathy Acetylcholinesterase deficiency Heart failure Autophagy Astrocytes Alternative splicing Aging Muscular dystrophy Myotonic Dystrophy type 1 Dystrophie Myotonique Acute coronary syndrome RNA interference Cardiac muscle CTG repeat instability Dystrophie myotonique Cell culture model ARN KNOCKOUT MICE Gene editing Fibrosis CMS Exercise RNA biology Dystrophin CRISPR/Cas9 Exercice Trinucleotide Repeat Expansion DM1 Cultured Antisense oligonucleotide Hypoxia Expression Thérapie génique Myotonic dystrophy MBNL Acetylcholinesterase knockout mouse Trinucleotide repeat expansion Myotonic dystrophy mouse models Mouse model CRISPRi DMSXL mice Myostatin Myotonic dystrophy type 1 CONGENITAL MYATHENIC SYNDROME Mice Therapy Genotype phenotype correlation Motoneuron Antisense oligonucleotides CTG repeats Muscle Central nervous system Astrocyte PacBio Cytoskeleton Mouse models Cell model Transcriptomics Gene therapy Brain dysfunction Gene Therapy Animals Myotonic Dystrophy Type 1 Male Heart Centronuclear myopathy Oligodendrocytes AAV Myotonic Dystrophy GSK3␤ BIOLOGIE MOLECULAIRE Diaphragm PCR Transgenic mouse Neuron Quantitative microdialysis Cell penetrating peptide Endurance training Long read sequencing GABA Desmin Duchenne muscular dystrophy Myelin Maximal force Humans Oligodendrocyte RNA splicing Transgenic mouse model ACETYLCHOLINESTERASE DMPK Intermediate filament Skeletal muscle Brain Cells Dynamin 2 Glucocorticoids Glucocorticoid-receptor